>Beetlejuice, Sam and Max, The Tick, Night Hood, Men In Black the Series, Batman the Animated Series, Courage the Cowardly Dog, Adventure Time, Regular Show, Avatar Series (including both shows in that header) Early Seasons of The Real Ghostbusters and XGB overall. Gravity Falls, Samurai Jack, Jimmy Two Shoes.
Every single one of those was aimed at children. Except possibly Night Hood, which I've never heard of.
Don't get me wrong, they're good shows. But they're doing nothing to prove that there's much western animated content that isn't aimed at either children or college-aged stoners.
I'd agree with the listing of Venture Brothers. It's got raunchy and humor from time to time, but it's not the focus. I'd probably list The Boondocks as well, and maaaaaaybe Archer. Archer's definitely got a lot of adult humor in it, but it doesn't feel like it's quite as reliant on shock humor as something like Family Guy or South Park would be.
Even with all of those, they're still comedies. I wish I could think of an animated action show that isn't aimed at children to list here, but the only examples I can think of have been off the air for years, like Aeon Flux or The Maxx.